Of Freedom, Country and Vaccination

[luka_skywalker_77]

@"Dahlsim"

Though this was interesting: https://stomson2001.wordpress.com/2021/0...e-systems/

"Anecdotes tell us what the data can’t: Vaccinated people appear to be getting the coronavirus at a surprisingly high rate. But exactly how often isn’t clear, nor is it certain how likely they are to spread the virus to others. 

Though it is evident vaccination still provides powerful protection against the virus, there’s growing concern that vaccinated people may be more vulnerable to serious illness than previously thought.

ER Editor: Dr. Mike Williams does a sterling job of explaining the probable mechanism behind the mRNA vaccines and why they have been engineered to TURN OFF a key element in our immune system response (this element is particular TLRs or toll-like receptors). Turning off this component permits the mRNA to enter our cells to do its job. When these are neutralized or prevented from working, however, there is then a knock-on effect on the CD8 T-cells, which are vital to a robust immune-system response. As Dr. Ryan Cole refers to them in this article/tweet, they are your ‘killer’ cells which, among other things, keep viruses in check. When you turn off certain TLRs, you also disable these highly necessary T-cells.

Whoever thought this was good idea? 

All of which may explain why certain types of cancer, as well as shingles, seem to be on the rise following Covid vaccination."

The issue I have is how does this affect the immune system long term. I don't think it simply disappears after it's time in our body wanes and that is concerning. Thankfully, there are a lot of doctors and scientists out there studying this around the clock; something the mainstream of doctors won't do. And at least we can get real data from that--peer review is sh*te for the most part but at least the research is being done. 

Forgot to add: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833091/

Do COVID-19 RNA-based vaccines put at risk of immune-mediated diseases? In reply to “potential antigenic cross-reactivity between SARS-CoV-2 and human tissue with a possible link to an increase in autoimmune diseases”

[...] The reactogenicity of COVID-19 mRNA vaccine in individuals suffering from immune-mediated diseases and having therefore a pre-existent dysregulation of the immune response has not been investigated. It may be hypothesized that immunosuppressive agents prescribed to these patients mitigate or even prevent side effects related to vaccine immunogenicity.

Besides the mechanism of molecular mimicry, mRNA vaccines may give rise to a cascade of immunological events eventually leading to the aberrant activation of the innate and acquired immune system [...]

How it works: 
[...] RNA vaccines have been principally designed for cancer and infectious diseases. This innovative therapeutic approach is based on the synthesis of RNA chains coding for desired antigenic proteins and exploits the intrinsic immunogenicity of nucleic acids. In order to avoid degradation by RNases, RNA can be encapsulated in nanoparticles or liposomes, which deliver the cargo inside target cells following a process of endocytosis. mRNA is then translated into immunogenic proteins by cell ribosomal machinery [...]

Dangers: 
[...] However, prior to the translation, mRNA may bind pattern recognition receptors (PRRs) in endosomes or cytosol. Toll-like receptor (TLR)3, TLR7 and TLR8 are able to recognize chains of double-stranded (ds)RNA or single-stranded (ss)RNA in endosomes, while retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5) may detect short and long filaments of dsRNA in the cytosol. The final result is the activation of several pro-inflammatory cascades, including the assembly of inflammasome platforms, the type I interferon (IFN) response and the nuclear translocation of the transcription factor nuclear factor (NF)-kB 

Further concern: https://www.medrxiv.org/content/10.1101/...21256520v1 (under eval)
https://www.news-medical.net/news/202105...ant-Notice

The BNT162b2 mRNA vaccine against SARS-CoV-2 reprograms both adaptive and innate immune responses

[...] Here we confirmed that BNT162b2 vaccination of healthy individuals induced effective humoral and cellular immunity against several SARS-CoV-2 variants. Interestingly, however, the BNT162b2 vaccine also modulated the production of inflammatory cytokines by innate immune cells upon stimulation with both specific (SARS-CoV-2) and non-specific (viral, fungal and bacterial) stimuli. The response of innate immune cells to TLR4 and TLR7/8 ligands was lower after BNT162b2 vaccination, while fungi-induced cytokine responses were stronger. In conclusion, the mRNA BNT162b2 vaccine induces complex functional reprogramming of innate immune responses, which should be considered in the development and use of this new class of vaccines [...]