Of Freedom, Country and Vaccination

[dirkfansince1998]

From the article you linked.

All that said, some facts are well established at this point. Vaccinated people infected with the virus are much less likely to need to go to the hospital, much less likely to need intubation and much less likely to die from the illness. There’s no doubt that vaccines provide significant protection. But a large proportion of the nation -- almost 30% of U.S. adults -- have not been vaccinated, a fact that has conspired with the highly contagious delta variant to push the country into a new wave of outbreaks.
“The big picture here is that the vaccines are working and the reason for the spike in the U.S. is we have too little vaccine uptake,” Frieden said.


To clarify it one more time. Yes breakthrough infections are a thing. And with more people getting the vaccine we will see more and more of them. Bur the numbers are as clear as it gets. Maybe a visual presentation can help.


Same for hospitalizations:

Summary

• For all adults aged 18 years and older, the cumulative COVID-19-associated hospitalization rate was about 12-times higher in unvaccinated persons.
  
• Although weekly rates can vary, the cumulative rate of COVID-19-associated hospitalizations in unvaccinated adults ages 18–49 years was about 14-times higher than fully vaccinated adults aged 18–49 years.
  
• Although weekly rates can vary widely, the cumulative rate of COVID-19-associated hospitalizations in unvaccinated adults ages 50–64 years was about 15-times higher than fully vaccinated adults aged 50–64 years.
  
• Although weekly rates can vary widely, the cumulative rate of COVID-19-associated hospitalizations in unvaccinated adults ages 65 years and older was about 9-times higher than fully vaccinated adults ages 65 years and older.
  

https://covid.cdc.gov/covid-data-tracker...ine-status


Not sure what I should tell you about Dr. Williams and Dr. Cole. First of all Mr. Cole is free to provide evidence for his claims about cancer rates. So far he hasn´t done that. US cancer data is published at a later date so we don´t have any official US numbers. Looking around I couldn´t find any number to support his claim. Actually the opposite. Sadly we had less screening/testing. Leading to lower case numbers. Potentially more missed cases. Also a potential explanation for anectodal mentions of increasing numbers of cancer in advanced stages.

2nd part once again isn´t providing any evidence for the claims about suppressed killer cells. For all the people that aren´t into topics like this. We aren´t talking about COVID specific t-cells (As mentioned previously we can see a clear increase in CD4+ and CD8+ cells with vaccine).
Difficult to explain. Maybe the best way to say it. "We are talking about the specific mechanism that is used to prevent a immune response that would "attack" the vaccine. The mentioned toll-like receptors work like an alarm signal. They detect pathogens (more than just viruses, also important for cancer) and initiate the non specific + antibody/b/t cell response.
The developers of MRNA vaccines had to bypass this mechanism. To quote one of the developers:

“In the natural world, the body relies on millions of tiny proteins to keep itself alive and healthy, and it uses mRNA to tell cells which proteins to make. If you could design your own mRNA, you could, in theory, hijack that process and create any protein you might desire — antibodies to vaccinate against infection, enzymes to reverse a rare disease, or growth agents to mend damaged heart tissue […]
The problem, [Karikó] knew, was that synthetic RNA was notoriously vulnerable to the body’s natural defenses, meaning it would likely be destroyed before reaching its target cells. And, worse, the resulting biological havoc might stir up an immune response that could make the therapy a health risk for some patients.” (Dr Kaliko, co-author of the paper that Mr. Williams is refering to)

Question is. How to bypass the TLR. Answer of the paper. Modify the MRNA. Camouflage it. Prevent detection. For whatever reason Cole and Williams assume that the TLR is getting modified or to quote him turned off. That´s not what the paper is saying. It is not impacting the TLRs ability to detect other pathogens. Only thing that is getting modified is the MRNA.

The "camouflage" isn´t perfect and TLR will be stimulated just like in any other case. That´s actually wanted. At least to a certain degree. The "activation" triggers certain parts of the immune response. Especially b-cell activity. A "natural" adjuvant.

So much in theory. We obviously don´t know everything and as the study from the netherlands suggests further research is needed. Especially when it comes to potential mechanisms that trigger the innate immune response. We want to do that. But only to a certain degree.

Edit: Just found a summary that is better than anything I could provide. Just read this. Someone already adressed Cole´s statements.

https://healthfeedback.org/claimreview/n...ne-system/